At the
beginning of December, I did some venting about the miserable record of the
biopharmaceutical industry’s inability to slow, let alone cure, Alzheimer’s.
But on December 10, the lead article in the Boston
Globe’s business section was headlined “Hopes rise for approach to combat
Alzheimer’s.” Was this just another tease? The article, written by Robert
Weisman, suggested that the failure of Eli Lilly opened the door to
Cambridge-based Biogen. As with Eli Lilly’s failed drug candidate—solanezumab—Biogen’s
compound has a long name: aducanumab. On December 21, Weisman wrote about
Michel Vounatsos, Biogen’s incoming chief executive. The banner headline
stated, “Alzheimer’s is top challenge, Biogen CEO says.”
According to Weisman, recent research by Biogen confirmed
data indicating that aducanumab decreased levels of plaque among individuals
who continued to take the drug after the clinical trial was over. This was
encouraging—both to the people who took part in the clinical trial and, of
course, to Biogen and its investors. Yet Weisman noted that optimism was
“tempered” about the drug candidate because a biotechnology analyst estimated
that there was only about a 35 percent chance that the drug would ever be approved.
In the world of Alzheimer’s research, however, anything better than a
one-in-three chance sounds highly encouraging. Keep in mind, of course, that
the only Alzheimer’s drugs on the market today are Aricept and a few other
drugs, none of which claim the ability to hinder the disease’s progress, let
alone stop it. So any genuine progress to slow the disease would be a big deal.
But, as always with Alzheimer’s research, big challenges
lie ahead. One drawback: One of the people in the clinical trial suffered a
seizure. Weisman’s article did not make clear whether the seizure was directly
caused by aducanumab, and Samantha Budd Haeberlein, Biogen’s vice president of
clinical of discovery and development, took an optimistic view, suggesting that
the data from clinical trials “shows that we can take patients more slowly to
their designated doses and still see efficacy.”
Nothing will happen overnight, of course. According to
Weisman, Biogen’s forthcoming clinical trial will be mammoth—as many as 3,000
participants spread among twenty nations. Will I be volunteering? I hesitate
because I seem to be able to bear Aricept at only very low doses, and I suspect
that would be the case with the drug in the Biogen clinical trial as well. I
cherish my sleep—as anyone with Alzheimer’s should—and I’m wary of being
knocked off my daily regimen by poor sleep hygiene.
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